{"id":226384,"date":"2020-08-21T09:30:35","date_gmt":"2020-08-21T13:30:35","guid":{"rendered":"https:\/\/oncubanews.com\/en\/?p=226384"},"modified":"2020-08-21T09:30:35","modified_gmt":"2020-08-21T13:30:35","slug":"cuba-covid-19-vaccine-project-already-tested-on-three-researchers","status":"publish","type":"post","link":"https:\/\/oncubanews.com\/en\/cuba\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\/","title":{"rendered":"Cuba: COVID-19 vaccine project already tested on three researchers"},"content":{"rendered":"<p style=\"text-align: right;\"><a href=\"https:\/\/oncubanews.com\/contribute\/\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Help us keep OnCuba alive<\/em><\/a><\/p>\n<p>The Cuban <a href=\"https:\/\/oncubanews.com\/tag\/ciencia-cubana\/\" target=\"_blank\" rel=\"noopener noreferrer\">COVID-19<\/a> vaccine project, named Soberana 01, was already tested on July 28 on doctors Vicente V\u00e9rez, director of the Finlay Institute of Vaccines (IFV), Yuri Vald\u00e9s and Dagmar Garc\u00eda, all of them principal investigators of the vaccine candidate.<\/p>\n<p>After the test, the island\u2019s three scientists have developed \u201ca high immune response,\u201d which will be confirmed after the second dose is applied in the next few days, as explained by Dr. V\u00e9rez quoted by the official <em><a href=\"http:\/\/www.cubadebate.cu\/especiales\/2020\/08\/19\/primer-candidato-vacunal-de-cuba-contra-la-covid-19-comenzara-ensayo-clinico-el-24-de-agosto-fotos\/\" target=\"_blank\" rel=\"noopener noreferrer\">Cubadebate<\/a><\/em> website.<\/p>\n<p>With Soberana 01, Cuba took an Olympic leap to enter the select and reduced group of countries that have specific vaccine candidates against the SARS-CoV-2 coronavirus. In fact, the Cuban project is the first in Latin America and already has the authorization of the Cuban regulatory authority on these issues: the Center for State Control of Quality of Medicines (CEDMED).<\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"cxafjIJDwt\"><p><a href=\"https:\/\/oncubanews.com\/en\/cuba\/cuba-to-start-clinical-trials-of-its-own-vaccine-against-new-coronavirus\/\">Cuba to start clinical trials of its own vaccine against new coronavirus<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"&#8220;Cuba to start clinical trials of its own vaccine against new coronavirus&#8221; &#8212; OnCubaNews English\" src=\"https:\/\/oncubanews.com\/en\/cuba\/cuba-to-start-clinical-trials-of-its-own-vaccine-against-new-coronavirus\/embed\/#?secret=0Ixb9BdZxz#?secret=cxafjIJDwt\" data-secret=\"cxafjIJDwt\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p>The phase of clinical trials with the vaccine, identified by the acronym FINLAY-FR-1, will begin next Monday, and will be supplied to a group of 20 persons aged between 19 and 59 years old. A week later, the trial will be applied to another twenty volunteers between 60 and 80 years old.<\/p>\n<p>In the second phase, scheduled to begin on September 11, the sample will be expanded to 676 volunteers, including the 40 from the first phase.<\/p>\n<p>During the presentation of the vaccine project, Dr. V\u00e9rez referred to the \u201clow risks, few uncertainties and encouraging results\u201d recorded in the preclinical phase, in which the drug was tested in mice and rabbits, and remains on trials on other animals.<\/p>\n<figure id=\"attachment_226386\" aria-describedby=\"caption-attachment-226386\" style=\"width: 1076px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/oncubanews.com\/en\/wp-content\/uploads\/2020\/08\/Ensayos-clinicos-vacuna-coronavirus-Cuba-1.jpeg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-226386\" src=\"https:\/\/oncubanews.com\/en\/wp-content\/uploads\/2020\/08\/Ensayos-clinicos-vacuna-coronavirus-Cuba-1.jpeg\" alt=\"\" width=\"1076\" height=\"1080\" srcset=\"https:\/\/oncubanews.com\/en\/wp-content\/uploads\/2020\/08\/Ensayos-clinicos-vacuna-coronavirus-Cuba-1.jpeg 1076w, https:\/\/oncubanews.com\/en\/wp-content\/uploads\/2020\/08\/Ensayos-clinicos-vacuna-coronavirus-Cuba-1-300x300.jpeg 300w, https:\/\/oncubanews.com\/en\/wp-content\/uploads\/2020\/08\/Ensayos-clinicos-vacuna-coronavirus-Cuba-1-1020x1024.jpeg 1020w, https:\/\/oncubanews.com\/en\/wp-content\/uploads\/2020\/08\/Ensayos-clinicos-vacuna-coronavirus-Cuba-1-150x150.jpeg 150w, https:\/\/oncubanews.com\/en\/wp-content\/uploads\/2020\/08\/Ensayos-clinicos-vacuna-coronavirus-Cuba-1-768x771.jpeg 768w, https:\/\/oncubanews.com\/en\/wp-content\/uploads\/2020\/08\/Ensayos-clinicos-vacuna-coronavirus-Cuba-1-75x75.jpeg 75w, https:\/\/oncubanews.com\/en\/wp-content\/uploads\/2020\/08\/Ensayos-clinicos-vacuna-coronavirus-Cuba-1-750x753.jpeg 750w\" sizes=\"auto, (max-width: 1076px) 100vw, 1076px\" \/><\/a><figcaption id=\"caption-attachment-226386\" class=\"wp-caption-text\">Schedule of clinical trials for Soberana 01, Cuban COVID-19 vaccine candidate. Infographics: Juventud T\u00e9cnica.<\/figcaption><\/figure>\n<p><em><strong>*Caption:<\/strong><\/em><\/p>\n<p><strong>CUBAN VACCINE CANDIDATE vs COVID-19<\/strong><\/p>\n<p><strong>Acronym for abbreviated title<\/strong><\/p>\n<p>SOBERANA 01<\/p>\n<p><strong>Purpose<\/strong><\/p>\n<p>Prevent Covid-19<\/p>\n<p><strong>Principal promoter<\/strong><\/p>\n<p>Finlay Institute of Vaccines<\/p>\n<p><strong>Type of participants:<\/strong><\/p>\n<p>Healthy volunteers<\/p>\n<p><strong>Age group to be studied:<\/strong><\/p>\n<p>19-80 years<\/p>\n<p><strong>Size of sample:<\/strong><\/p>\n<p>675 individuals<\/p>\n<p><strong>Some inclusion criteria:<\/strong><\/p>\n<p>&gt;&gt; Giving consent in writing<\/p>\n<p>&gt;&gt; Being between 19-59 and 59-80 years old<\/p>\n<p>&gt;&gt; Corporal mass rate between 18 and 29.9 kg\/m<sup>2<\/sup><\/p>\n<p><strong>Study\u2019s key dates<\/strong><\/p>\n<p>First inclusion: 24\/08\/2020<\/p>\n<p>Last inclusion: 30\/10\/2020<\/p>\n<p>Termination: 11\/01\/2021<\/p>\n<p>Available results: 1\/02\/2021<\/p>\n<p>First publication: 15\/02\/2021<\/p>\n<p>According to Dr. Dagmar Garc\u00eda, on May 22 the RBD (Receptor Binding Domain) antigen was defined for the first time, because it is the most important protein fragment of the virus for its entry into the cell.<\/p>\n<p>\u201cThis protein fragment is precisely the region of the virus that interacts with a receptor of the human cell, to penetrate the cell, which is why the vaccine strategy is to direct antibodies against that structure of the virus, with the aim of blocking this interaction of the viral protein with its receptor in the host,\u201d stated Garc\u00eda, quoted by <em>Cubadebate<\/em>.<\/p>\n<p>The researchers wanted to use a vaccine platform in which they had previous experience, so they decided to combine this antigen with the meningococcal B outer membrane vesicle platform, which is the basis of the Cuban VA-MENGOC- BC\u00ae meningococcal meningitis vaccine.<\/p>\n<p>According to Dr. Garc\u00eda, \u201cthis element offers a lot of security to this vaccine candidate, because it is based on the platform of a vaccine that has been in use for more than 30 years. This immunogen also solved an epidemiological problem in the country and is used in the expanded immunization program, even in infants, with safety and high efficacy, which transmits peace of mind.\u201d<\/p>\n<p>https:\/\/twitter.com\/FinlayInstituto\/status\/1296268854138634244?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1296268854138634244%7Ctwgr%5E&#038;ref_url=https%3A%2F%2Foncubanews.com%2Fcuba%2Fcuba-proyecto-de-vacuna-contra-la-covid-19-ya-fue-probado-en-tres-investigadores%2F<\/p>\n<p>The research director of the Finlay Institute affirmed that, if the vaccine demonstrates efficacy in clinical trials, the island\u2019s biotechnology and pharmaceutical industry has the capacity to produce the millions of doses necessary to immunize the Cuban population, and even for export.<\/p>\n<p>Soberana 01 is the result of the collaboration of the Cuban government with <a href=\"https:\/\/oncubanews.com\/tag\/ciencia-cubana\/\" target=\"_blank\" rel=\"noopener noreferrer\">its scientific institutions<\/a> in the search for solutions to the COVID-19 pandemic.<\/p>\n<p>In addition to the Finlay Institute of Vaccines and the Molecular Immunology Center, the Faculty of Chemistry of the University of Havana, the molecular biology laboratory of the Civil Defense Research Center and the Center for Genetic Engineering and Biotechnology are participating in the project.<\/p>\n<p>The institutions\u2019 alliance also involves the National Toxicology Center as the main site for the candidate\u2019s clinical trials, and the Pedro Kour\u00ed Institute of Tropical Medicine (IPK).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Help us keep OnCuba alive The Cuban COVID-19 vaccine project, named Soberana 01, was already tested on July 28 on doctors Vicente V\u00e9rez, director of the Finlay Institute of Vaccines (IFV), Yuri Vald\u00e9s and Dagmar Garc\u00eda, all of them principal investigators of the vaccine candidate. After the test, the island\u2019s three scientists have developed \u201ca [&hellip;]<\/p>\n","protected":false},"author":3134,"featured_media":226385,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[13902],"tags":[29532,32668,15273],"ppma_author":[33546,8689],"class_list":["post-226384","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cuba","tag-coronavirus-in-cuba","tag-covid-19-vaccine","tag-cuban-science"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cuba: COVID-19 vaccine project already tested on three researchers | OnCubaNews English<\/title>\n<meta name=\"description\" content=\"After the test, the scientists have developed \u201ca high immune response,\u201d which will be confirmed after the second dose is applied in the next few days. 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In addition, the island will begin the clinical trials phase of Soberana 01 next Monday, with the administration of the drug to 40 people, and will extend the sample to 676 volunteers during the second phase, in September.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/oncubanews.com\/en\/cuba\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\/\" \/>\n<meta property=\"og:site_name\" content=\"OnCubaNews English\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-21T13:30:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/oncubanews.com\/en\/wp-content\/uploads\/2020\/08\/vacuna-cubana-covid-2-750x489-1.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"750\" \/>\n\t<meta property=\"og:image:height\" content=\"489\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"OnCuba Staff, OnCuba editorial staff\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"OnCuba Staff\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/cuba\\\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/cuba\\\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\\\/\"},\"author\":{\"name\":\"OnCuba Staff\",\"@id\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/#\\\/schema\\\/person\\\/d7171bf311032ab1f557dd8332e714af\"},\"headline\":\"Cuba: COVID-19 vaccine project already tested on three researchers\",\"datePublished\":\"2020-08-21T13:30:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/cuba\\\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\\\/\"},\"wordCount\":742,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/cuba\\\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/wp-content\\\/uploads\\\/2020\\\/08\\\/vacuna-cubana-covid-2-750x489-1.jpg\",\"keywords\":[\"coronavirus in Cuba\",\"COVID-19 vaccine\",\"Cuban science\"],\"articleSection\":[\"Cuba\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/oncubanews.com\\\/en\\\/cuba\\\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\\\/#respond\"]}],\"copyrightYear\":\"2020\",\"copyrightHolder\":{\"@id\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/#organization\"}},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/cuba\\\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\\\/\",\"url\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/cuba\\\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\\\/\",\"name\":\"Cuba: COVID-19 vaccine project already tested on three researchers | OnCubaNews English\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/cuba\\\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/cuba\\\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/wp-content\\\/uploads\\\/2020\\\/08\\\/vacuna-cubana-covid-2-750x489-1.jpg\",\"datePublished\":\"2020-08-21T13:30:35+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/oncubanews.com\\\/en\\\/#\\\/schema\\\/person\\\/d7171bf311032ab1f557dd8332e714af\"},\"description\":\"After the test, the scientists have developed \u201ca high immune response,\u201d which will be confirmed after the second dose is applied in the next few days. 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In addition, the island will begin the clinical trials phase of Soberana 01 next Monday, with the administration of the drug to 40 people, and will extend the sample to 676 volunteers during the second phase, in September.","breadcrumb":{"@id":"https:\/\/oncubanews.com\/en\/cuba\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/oncubanews.com\/en\/cuba\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/oncubanews.com\/en\/cuba\/cuba-covid-19-vaccine-project-already-tested-on-three-researchers\/#primaryimage","url":"https:\/\/oncubanews.com\/en\/wp-content\/uploads\/2020\/08\/vacuna-cubana-covid-2-750x489-1.jpg","contentUrl":"https:\/\/oncubanews.com\/en\/wp-content\/uploads\/2020\/08\/vacuna-cubana-covid-2-750x489-1.jpg","width":750,"height":489,"caption":"Cuban vaccine candidate, Soberana 01. 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