{"id":233705,"date":"2021-01-26T12:25:44","date_gmt":"2021-01-26T17:25:44","guid":{"rendered":"https:\/\/oncubanews.com\/en\/?p=233705"},"modified":"2021-01-26T12:25:44","modified_gmt":"2021-01-26T17:25:44","slug":"clinical-trial-in-people-convalescing-from-covid-19-carried-out-in-cuba","status":"publish","type":"post","link":"https:\/\/oncubanews.com\/en\/cuba\/clinical-trial-in-people-convalescing-from-covid-19-carried-out-in-cuba\/","title":{"rendered":"Clinical trial in people convalescing from COVID-19 carried out in Cuba"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Cuba is carrying out a clinical trial in people convalescing from <\/span><a href=\"https:\/\/oncubanews.com\/tag\/coronavirus\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">COVID-19<\/span><\/a><span style=\"font-weight: 400;\">, who had a minor clinical picture or were asymptomatic, the official media reported.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The study uses the Soberana 01 vaccine candidate, the first to receive authorization in Cuba for tests on human beings, and seeks to \u201cstimulate protective levels of neutralizing antibodies against possible reinfection,\u201d <em>Prensa Latina (PL)<\/em> agency <\/span><a href=\"https:\/\/www.prensa-latina.cu\/index.php?o=rn&amp;id=425937&amp;SEO=cuba-se-prepara-para-proteger-a-convalecientes-de-covid-19\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">reported<\/span><\/a><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The agency recalled that \u201cglobally there are cases of people infected with this coronavirus who were reinfected, even with much more acute and serious forms of the disease,\u201d which is why the trial that is taking place on the island \u201calso seeks to protect this risk group.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The test began on January 9 at the Institute of Hematology and Immunology and involves 30 volunteers, aged 19 to 59, \u201cwho were in contact with the virus and currently have a negative PCR.\u201d These people received a single dose of the vaccine on day 16 and \u201cfrom that moment on, they are being closely monitored through doctor\u2019s offices and direct contact with the researchers.\u201d<\/span><\/p>\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\">\n<p lang=\"es\" dir=\"ltr\"><a href=\"https:\/\/twitter.com\/hashtag\/Soberana01?src=hash&amp;ref_src=twsrc%5Etfw\">#Soberana01<\/a>: El ensayo comenz\u00f3 el pasado d\u00eda 9 de enero con reclutamiento de 30 voluntarios entre 19 y 59 a\u00f1os de edad, y continu\u00f3 con la vacunaci\u00f3n el 16 de enero.\u00a0Ahora se realiza consulta de seguimiento, para evaluar la respuesta inmune.<a href=\"https:\/\/twitter.com\/hashtag\/CienciaCubana?src=hash&amp;ref_src=twsrc%5Etfw\">#CienciaCubana<\/a><a href=\"https:\/\/t.co\/tT02RkVdN0\">https:\/\/t.co\/tT02RkVdN0<\/a><\/p>\n<p>&mdash; Instituto Finlay de Vacunas (@FinlayInstituto) <a href=\"https:\/\/twitter.com\/FinlayInstituto\/status\/1353283635261140992?ref_src=twsrc%5Etfw\">January 24, 2021<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<p><span style=\"font-weight: 400;\">Dr. Rolando Ochoa, a specialist in Immunology at the Finlay Vaccine Institute, explained that the formulation of Soberana 01 used in the test \u201cis simpler and safer, according to the characteristics of the population group under study.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The expert argued that the vaccination was carried out in people convalescing from the disease, \u201cwho have low levels of neutralizing antibodies and, therefore, may be susceptible to reinfection,\u201d <\/span><i><span style=\"font-weight: 400;\">Granma<\/span><\/i><span style=\"font-weight: 400;\"> newspaper <\/span><a href=\"http:\/\/www.granma.cu\/cuba-covid-19\/2021-01-23\/soberana-01-tambien-avanza-con-paso-firme-contra-la-covid-19-23-01-2021-13-01-35\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">noted<\/span><\/a><span style=\"font-weight: 400;\"> in this regard.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">For his part, Dr. Arturo Chang, a specialist at the Institute of Hematology and Immunology, said that the study follows \u201cthe premise that these people were already vaccinated naturally (through contact with the virus), which is why this dose would be a boost to the individual\u2019s immunity.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The also principal investigator of the trial, which lasts for 28 days, explained that, \u201calthough what is conventional in phase I trials is that healthy and young people are chosen, the difference with this is that, when working with a population that already was in contact with the virus, it made it possible to include volunteers with some chronic pathology, but who are compensated.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In addition, he specified, quoted by <\/span><i><span style=\"font-weight: 400;\">Granma<\/span><\/i><span style=\"font-weight: 400;\">, that \u201ca second premise is related to the fact that the percentages of inhibition of antibodies against SARS-CoV-2 are relatively low, that is, that the person has not been immunized against the virus.\u201d For this reason, he said \u201cthis trial is a novelty around the world, since the research has focused on the population sector that has not become ill.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Chang stated that so far \u201cthere are no serious adverse events\u201d and said that \u201cif positive results are achieved in this phase, they will probably go on to a clinical trial with a larger number of subjects to evaluate the immunogenicity, efficacy and effectiveness of the product.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cuba has to date four COVID-19 vaccine candidates in the testing phase in humans: Soberana 01 and 02, both from the Finlay Institute, and Mambisa and Abdala, from the Center for Genetic Engineering and Biotechnology. Of these, Soberana 02 is the most advanced as it is already developing its phase II and Cuban scientists are confident that it can soon <\/span><a href=\"https:\/\/oncubanews.com\/cuba\/cuba-fase-iii-de-ensayos-clinicos-de-vacuna-anti-covid-podria-empezar-en-marzo\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">move on to phase III<\/span><\/a><span style=\"font-weight: 400;\"> and be used in mass vaccination. To do this, they hope to <\/span><a href=\"https:\/\/oncubanews.com\/en\/cuba\/coronavirus-cuba-will-produce-100-million-doses-of-its-soberana-02-vaccine\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">produce 100 million doses<\/span><\/a><span style=\"font-weight: 400;\"> this year.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cuba is carrying out a clinical trial in people convalescing from COVID-19, who had a minor clinical picture or were asymptomatic, the official media reported. The study uses the Soberana 01 vaccine candidate, the first to receive authorization in Cuba for tests on human beings, and seeks to \u201cstimulate protective levels of neutralizing antibodies against [&hellip;]<\/p>\n","protected":false},"author":3134,"featured_media":233706,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[13902],"tags":[29532,15273,33386],"ppma_author":[33546,8689],"class_list":["post-233705","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cuba","tag-coronavirus-in-cuba","tag-cuban-science","tag-cuban-vaccine-against-covid-19"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Clinical trial in people convalescing from COVID-19 carried out in Cuba | OnCubaNews English<\/title>\n<meta name=\"description\" content=\"The 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