
{"id":239795,"date":"2021-06-01T15:02:15","date_gmt":"2021-06-01T19:02:15","guid":{"rendered":"https:\/\/oncubanews.com\/en\/?p=239795"},"modified":"2021-06-01T15:02:15","modified_gmt":"2021-06-01T19:02:15","slug":"convalescents-vaccinated-with-soberana-plus-have-highest-amount-of-antibodies-against-the-coronavirus-in-cuba","status":"publish","type":"post","link":"https:\/\/oncubanews.com\/en\/coronavirus\/convalescents-vaccinated-with-soberana-plus-have-highest-amount-of-antibodies-against-the-coronavirus-in-cuba\/","title":{"rendered":"Convalescents vaccinated with Soberana Plus have highest amount of antibodies against the coronavirus in Cuba"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">About to conclude the inoculation of the volunteers of phase II clinical trial with the Cuban <\/span><a href=\"https:\/\/oncubanews.com\/en\/tag\/cuban-vaccine-against-covid-19\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Soberana Plus<\/span><\/a><span style=\"font-weight: 400;\"> vaccine candidate, its developers affirm that the convalescents from <\/span><a href=\"https:\/\/oncubanews.com\/en\/coronavirus\/\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">COVID-19<\/span><\/a><span style=\"font-weight: 400;\"> who received this drug are those with the most antibodies against the coronavirus in Cuba.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The principal investigator of the clinical trials, Arturo Chang, pointed out that as part of the studies, the levels of antibodies have been evaluated, which turned out to be higher than those of convalescent patients without vaccination compared to those who received two doses of Soberana 02 plus the booster dose of Soberana Plus, reported the <\/span><a href=\"http:\/\/www.acn.cu\/salud\/80206-prometedores-resultados-de-soberana-plus-con-convalecientes-de-la-covid-19\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">Agencia Cubana de Noticias (ACN)<\/span><\/a><span style=\"font-weight: 400;\"> news agency.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cited by the agency, Chang clarified that these results were obtained in a previous Phase I trial based on the comparison of the antibodies developed by those inoculated with the injectable, created by the Finlay Vaccine Institute, in relation to those produced naturally when infected with SARS-CoV-2.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u201cThose people who recovered from the disease and were left with high antibody titers became part of the robust panel of Cuban convalescents, difficult to overcome, but after a dose of Soberana Plus in those who suffered from the virus \u2014 and were left with low antibody titers \u2014 it was possible to match and even exceed the panel,\u201d explained the expert, who, however, did not offer figures to detail the comparison.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Likewise, the specialist stressed that the vaccine candidate has the potential to increase the immunity of convalescents with the application of a single dose, and assured that so far few adverse events have been registered \u201cso it does not offer any risk to elderly people.\u201d<\/span><\/p>\n<blockquote class=\"wp-embedded-content\" data-secret=\"EZKDRDSulU\"><p><a href=\"https:\/\/oncubanews.com\/cuba\/en-la-recta-final-ensayo-clinico-fase-ii-del-candidato-vacunal-cubano-soberana-plus\/\">En la recta final ensayo cl\u00ednico fase II del candidato vacunal cubano Soberana Plus<\/a><\/p><\/blockquote>\n<p><iframe loading=\"lazy\" class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; clip: rect(1px, 1px, 1px, 1px);\" title=\"\u00abEn la recta final ensayo cl\u00ednico fase II del candidato vacunal cubano Soberana Plus\u00bb \u2014 OnCubaNews\" src=\"https:\/\/oncubanews.com\/cuba\/en-la-recta-final-ensayo-clinico-fase-ii-del-candidato-vacunal-cubano-soberana-plus\/embed\/#?secret=Wwc02qTCCI#?secret=EZKDRDSulU\" data-secret=\"EZKDRDSulU\" width=\"500\" height=\"282\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe><\/p>\n<p><span style=\"font-weight: 400;\">Chang said that several of the participants in the clinical trial have been in direct contact with SARS-CoV-2 positive cases and so far none have been infected. He also recalled that Soberana Plus is used as a booster dose in one of Soberana 02\u2019s vaccination schedules, although he did not rule out that it could be used to reinforce the immunization of other Cuban vaccine candidates and even foreign vaccines.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The drug also serves to increase antibody titers in convalescent patients who are donors of the plasma used in the manufacture of hyperimmune gamma globulin against SARS-CoV-2, which is used in the treatment of COVID-19 patients in serious and critical stages, the researcher added.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Regarding the Phase II clinical trial, Chang explained that \u201cit was practically a Phase III design, except for having a smaller number of volunteers,\u201d but he specified that \u201cit did include convalescent patients with compensated chronic diseases and from the 60- to 80-year-old group.\u201d He said that the study was divided into a Phase IIA, with 20 subjects, and a Phase IIB with 430 convalescents, the last of which will have been immunized after 28 days on June 7.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">As of that date, the volunteers who received placebo will be vaccinated, \u201cso that all the convalescent patients who were included can be protected,\u201d concluded the specialist.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The principal investigator of the clinical trials, Arturo Chang, pointed out that as part of the studies, the levels of antibodies have been evaluated, which turned out to be higher than those of convalescent patients without vaccination compared to those who received two doses of Soberana 02 plus the booster dose of Soberana Plus.<\/p>\n","protected":false},"author":3134,"featured_media":239797,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[33393,13916],"tags":[15273,33386,33462],"ppma_author":[33546],"class_list":["post-239795","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-coronavirus","category-science-in-cuba","tag-cuban-science","tag-cuban-vaccine-against-covid-19","tag-soberana-02"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Convalescents vaccinated with Soberana Plus have highest amount of antibodies against the coronavirus in Cuba | OnCubaNews English<\/title>\n<meta name=\"description\" content=\"The principal investigator of the clinical trials, Arturo Chang, pointed out that as part of the studies, the levels of antibodies have been 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