{"id":267183,"date":"2023-03-24T16:14:26","date_gmt":"2023-03-24T20:14:26","guid":{"rendered":"https:\/\/oncubanews.com\/en\/?p=267183"},"modified":"2023-03-24T16:14:26","modified_gmt":"2023-03-24T20:14:26","slug":"safety-of-technological-platform-of-cuban-dengue-vaccine-candidate-validated","status":"publish","type":"post","link":"https:\/\/oncubanews.com\/en\/cuba\/safety-of-technological-platform-of-cuban-dengue-vaccine-candidate-validated\/","title":{"rendered":"Safety of technological platform of Cuban dengue vaccine candidate validated"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">The <\/span><a href=\"https:\/\/oncubanews.com\/en\/tag\/dengue\/\" target=\"_blank\" rel=\"noopener\"><b>dengue<\/b><\/a><span style=\"font-weight: 400;\">\u00a0vaccine candidate Cuba is developing has a safe technological platform, the Center for Genetic Engineering and Biotechnology (CIGB) reported this Tuesday.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The scientific institution assured on its Twitter account that the possible drug \u201cis based on recombinant proteins: a very safe technological platform,\u201d according to a <\/span><a href=\"https:\/\/www.prensa-latina.cu\/2023\/03\/21\/candidato-vacunal-de-cuba-contra-el-dengue-tiene-plataforma-segura\" target=\"_blank\" rel=\"noopener\"><b>dispatch<\/b><\/a><span style=\"font-weight: 400;\">\u00a0from Prensa Latina (PL) news agency.<\/span><\/p>\n<blockquote class=\"twitter-tweet\" data-width=\"500\" data-dnt=\"true\">\n<p lang=\"es\" dir=\"ltr\">El candidato vacunal contra dengue que estamos desarrollando en el <a href=\"https:\/\/twitter.com\/CIGBCuba?ref_src=twsrc%5Etfw\">@CIGBCuba<\/a> est\u00e1 basado en prote\u00ednas recombinantes: una plataforma tecnol\u00f3gica muy segura. Tenemos un candidato tetravalente, basado en prote\u00ednas de los 4 virus del dengue, que estamos evaluando en este momento. <a href=\"https:\/\/t.co\/c3wG7OSZ1Q\">pic.twitter.com\/c3wG7OSZ1Q<\/a><\/p>\n<p>&mdash; CIGBCuba (@CIGBCuba) <a href=\"https:\/\/twitter.com\/CIGBCuba\/status\/1638099878839738368?ref_src=twsrc%5Etfw\">March 21, 2023<\/a><\/p><\/blockquote>\n<p><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script><\/p>\n<p><span style=\"font-weight: 400;\">The message specifies that the center\u2019s experts have a tetravalent candidate, based on proteins from the four dengue viruses, which is currently in the \u201cevaluation phase,\u201d although the institution did not advance a possible date for the conclusion of the studies.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">If the level of dengue virus infection (viral load) is lowered, severity is avoided; even the symptoms, adds the publication.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The CIGB commented on the social network that this is precisely the objective of the drug they are developing so that the disease is subclinical or with mild symptoms, the report added.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Obtaining the vaccine is a complex process. Dengue has four serotypes and it is necessary to immunize against each of them at the same time for the product to be effective.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">PL recalls that in the course of 2023, a new rapid diagnosis system for dengue should be available, in which specialists from the Immunoassay Center are working.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In statements to <\/span><i><span style=\"font-weight: 400;\">Granma<\/span><\/i><span style=\"font-weight: 400;\"> newspaper quoted by the outlet, Eduardo Mart\u00ednez, president of the Biotechnological and Pharmaceutical Industries Business Group, argued that this system would allow determining, upon the appearance of the first symptoms, whether it is dengue or a second infection.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">This will serve to apply a differentiated treatment to patients, and avoid the worsening of the disease and death, Mart\u00ednez added then.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dengue is transmitted through the bite of an infected <\/span><i><span style=\"font-weight: 400;\">Aedes aegypti<\/span><\/i><span style=\"font-weight: 400;\"> mosquito and causes symptoms that can be mild or severe. They range from headaches, muscle and joint pain, and erythema fever, according to medical literature.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In the world, 2.5 billion people live at risk of getting dengue and it is precisely the summer and autumn months in which, due to the rains and the increase in temperatures, the mosquito infestation skyrockets, and this increases the possibility of transmission of the disease.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Cuba, due to its status as a tropical country, is prone to spikes in the incidence of this disease, which in its most serious cases can cause death.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">The situation became extremely complex during the most recent transmission peak, also marked by the deep economic crisis in the country, which makes it difficult to acquire supplies and carry out the necessary actions to mitigate the risks and treat the sick.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In July 2022, the Ministry of Public Health (MINSAP) reported that Cuba had broken the record for the number of reproduction points of the dengue-transmitting mosquito for the second year in 15 years, while in September the head of that ministry confirmed the transmission of the virus in the 15 provinces while warning about the high infestation rates of the transmitting agent.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The developers of the drug assure that the objective is to decrease the viral load of the dengue virus so that the disease is subclinical or with mild 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